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| Section | Objectives |
|---|---|
| Topic 1: Part II: Applied Clinical Decision Making | - Case-based pharmacotherapy scenarios
|
| Topic 2: Special Populations | - Renal and hepatic impairment
|
| Topic 3: Disease State Management | - Endocrine and metabolic disorders
|
| Topic 4: Patient Care and Pharmacotherapy Principles | - Therapeutic decision making
|
| Topic 5: Part I: Knowledge-Based Assessment | - Foundational pharmacotherapy knowledge
|
1. The Randomized Aldactone Evaluation Study (RALES) yielded the following results:
* Placebo death rate: 386/841
* Spironolactone death rate: 284/822
Given these data, which of the following is the relative risk reduction for death with spironolactone, in comparison with placebo?
A) 24%
B) 45%
C) 31%
D) 11%
2. A 72-year-old man has chronic insomnia that has not responded to measures to improve sleep hygiene. The patient is not depressed and has no other chronic health problems. It is determined that medication use will probably be necessary to manage the insomnia. What is the best initial recommendation for this patient?
A) Amitriptyline
B) Diphenhydramine
C) Trazodone
D) Alprazolam
3. A 38-year-old man with stage II testicular cancer has received a 5-day course of Cisplatin and etoposide, followed by daily Filgrastim. On day 14, he reports duki aching bone pain. Which of the following is the most likely cause of this complaint?
A) Etoposide
B) Disease progression
C) Cisplatin
D) Filgrastim
4. Using a new assay, the following readings for Drug X concentration in a blood sample are obtained: 45 ng/mL, 43 ng/mL, 45 ng/mL, 44 ng/mL, 45 ng/mL, and 45 ng/mL. The true concentration of the drug was reported as 65 ng/mL using the gold-standard assay.
On the basis of these data, the new assay should be characterized in which of the following categories?
A) Accurate but not precise
B) Both accurate and precise
C) Neither accurate nor precise
D) Precise but not accurate
5. Administration of a marketed drug to a patient for an off-label indication without approval from a local IRB is permissible in which of the following situations?
A) The patient's physician considers that the risk/benefit ratio favors the use of the drug.
B) The drug is administered under a protocol sponsored by an NIH grant.
C) The drug is administered on the request of the patient or the patient's representative.
D) The patient's physician has filed a Notice of Claimed Investigational Exemption for a New Drug with the FDA.
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: C | Question # 3 Answer: D | Question # 4 Answer: D | Question # 5 Answer: A |
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